23. Shields, J. D.; Ahneman, D. T.; Graham, T. J. A.; Doyle, A. G. “Enantioselective, Nickel-Catalyzed Suzuki Cross-Coupling of Quinolinium Ions.” Org. Lett. 2013, xx, xxx. [DOI: 10.1021/ol4031364]
22. Nielsen, D. K.; Huang, C.-Y.; Doyle, A. G. “Directed Nickel-Catalyzed Negishi Cross Coupling of Alkyl Aziridines.” J. Am. Chem. Soc. 2013, 135, 13605–13609. [DOI: 10.1021/ja407223g]
20. Chau, S. T.; Lutz, J. P.; Wu, K.; Doyle, A. G. “Nickel-Catalyzed Enantioselective Arylation of Pyridinium Ions: Harnessing an Iminium Ion Activation Mode.” Angew. Chem. Int. Ed. 2013, 52, 9153-9156. [DOI: 10.1002/anie.201303994] Highlighted in Synfacts.
19. Kalow, J. A.; Doyle, A. G. “Enantioselective fluoride ring opening of aziridines enabled by cooperative Lewis acid catalysis.” Tetrahedron 2013, 69, 5702-5709. [DOI: 10.1016/j.tet.2013.01.062] In honor of Professor Melanie Sanford on the occasion of her receipt of the Tetrahedron Young Investigator Award. Highlighted in Synfacts.
18. Braun, M.-G.;‡ Katcher, M. H.;‡ Doyle, A. G. “Carbofluorination via a palladium-catalyzed cascade reaction.” Chem. Sci. 2013, 4, 1216–1220.(‡ Equal contribution) [DOI: 10.1039/C2SC22198E] The most read article in January. One of the most downloaded articles between January-March.
17. Sylvester, K. T.;‡ Wu, K.;‡ Doyle, A. G. “Mechanistic Investigation of the Nickel-Catalyzed Suzuki Reaction of N,O-Acetals: Evidence for Boronic Acid-Assisted Oxidative Addition and an Iminium Activation Pathway.” J. Am. Chem. Soc. 2012, 134, 16967-16970. (‡ Equal contribution) [DOI: 10.1021/ja3079362]
16. Kalow, J. A.; Schmitt, D. E.; Doyle, A. G. “Synthesis of β-Fluoroamines by Lewis Base Catalyzed Hydrofluorination of Aziridines.” J. Org. Chem. 2012, 77, 4177–4183. [DOI: 10.1021/jo300433a] One of the most downloaded papers in April.
15. Huang, C.-Y.; Doyle, A. G. “Nickel-Catalyzed Negishi Alkylations of Styrenyl Aziridines.” J. Am. Chem. Soc. 2012, 134, 9541–9544. [DOI: 10.1021/ja3013825] One of the most downloaded papers in March. Featured in JACS Spotlight and on the issue’s cover. Highlighted in Synfacts.
14. Graham, T. J. A.; Doyle, A. G. “Nickel-Catalyzed Cross-Coupling of Chromene Acetals and Boronic Acids.” Org. Lett. 2012, 14, 1616–1619. [DOI: 10.1021/ol300364s] One of the most downloaded papers in March. Featured in OPRD.
13. Katcher, M. H.; Sha, A.; Doyle, A. G. “Palladium-Catalyzed Regio- and Enantioselective Fluorination of Acyclic Allylic Halides.” J. Am Chem. Soc. 2011, 133, 15902–15905. [DOI: 10.1021/ja206960k] One of the most downloaded articles in September. Highlighted in Synfacts.
12. Kalow, J. A.; Doyle, A. G. “Mechanistic Investigations of Cooperative Catalysis in the Enantioselective Fluorination of Epoxides.” J. Am. Chem. Soc. 2011, 133, 16001–16012. [DOI: 10.1021/ja207256s] Highlighted in Synfacts.
11. Shaw, T. W.; Kalow, J. A.; Doyle, A. G. “Fluoride Ring-Opening Kinetic Resolution of Terminal Epoxides: Preparation of (S)-2-Fluoro-1-Phenylethanol.” Org. Synth. 2012, 89, 9–18. [link] Featured article on Org. Synth. homepage.
10. Nielsen, D. K.; Doyle, A. G. “Nickel-Catalyzed Cross Coupling of Styrenyl Epoxides with Boronic Acids.” Angew. Chem., Int. Ed. 2011, 50, 6056–6059. [DOI: 10.1002/anie.201101191] Highlighted in Synfacts and OPRD.
9. Graham, T. J. A.; Shields, J. D.; Doyle, A. G. “Transition Metal-Catalyzed Cross Coupling with N-Acyliminium Ions Derived from Quinolines and Isoquinolines.” Chem. Sci. 2011, 2, 980–984. [DOI: 10.1039/c1sc00026h] One of the most downloaded articles in February.
8. Katcher, M. H.; Doyle, A. G. “Palladium-Catalyzed Asymmetric Synthesis of Allylic Fluorides.” J. Am. Chem. Soc. 2010, 132, 17402–17404. [DOI: 10.1021/ja109120n] Highlighted in OPRD. One of the most downloaded articles in November.
7. Kalow, J. A.; Doyle, A. G. “Enantioselective Ring Opening of Epoxides by Fluoride Anion Promoted by a Cooperative Dual Catalyst System.” J. Am. Chem. Soc. 2010, 132, 3268–3269. [DOI: 10.1021/ja100161d] Highlighted in Synfacts, Synform, and OPRD. One of the most downloaded articles in February.
6. Reisman, S. E.; Doyle, A. G.; Jacobsen, E. N. “Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions.” J. Am. Chem. Soc. 2008, 130, 7198–7199. [DOI: 10.1021/ja801514m]
5. Doyle, A. G.; Jacobsen, E. N. “Small-Molecule H-Bond Donors in Asymmetric Catalysis.” Chem. Rev. 2007, 107, 5713–5743. [DOI: 10.1021/cr068373r]
4. Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylation of Acyclic α,α-Disubstituted Tributyltin Enolates Catalyzed by a Cr(salen) Complex.” Angew. Chem. Int. Ed. 2007, 46, 3701–3705. [DOI: 10.1002/anie.200604901]
3. Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All-Carbon Quaternary Centers.” J. Am. Chem. Soc. 2005, 127, 62–63. [DOI: 10.1021/ja043601p]
2. Ellsworth, B. A.; Doyle, A. G.; Patel, M.; Caceres-Cortes, J.; Meng, W.; Deshpande, P. P.; Pullockaran, A.; Washburn, W. N. “C-Arylglucoside synthesis: triisopropylsilane as a selective reagent for the reduction of an anomeric C-phenyl ketal.” Tetrahedron: Asymmetry 2003, 14, 3243–3247. [DOI: 10.1016/j.tetasy.2003.08.007]
1. White, M. C.; Doyle, A. G.; Jacobsen, E. N. “A Synthetically Useful, Self-Assembling MMO Mimic System for Catalytic Alkene Epoxidation with Aqueous H2O2.” J. Am. Chem. Soc. 2001, 123, 7194–7195. [DOI: 10.1021/ja015884g] Highlighted in Chem. & Eng. News.