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Research Focus

Preparing molecules of interest via new catalyst design is a defining feature of modern organic chemistry. Despite tremendous advances, classical approaches such as organocatalysis and transition metal catalysis have difficulty addressing synthetic challenges. Our research group is interested in exploiting protein-based catalysts to address these challenges. These solutions range from developing new protein/catalysts hybrid complexes to engineering existing enzyme complexes to catalyze new, synthetically interesting reactions.

The aim of these new transformations will, in part, focus on the synthesis of nitrogen containing molecules. Basic nitrogen is found in the vast majority of medicinally and biologically relevant targets. The ability to access new types of nitrogen containing molecules can potentially lead to the discovery of new biological entities.

Research Areas
Catalysis / Synthesis
Honors

NIH-Ruth L. Kirschstein NRSA Fellowship (2013-2015)        

Reaxys PhD Prize Finalist (2014)                       

Aldrich Graduate Student Innovation Award (2013)

Marie Curie Fellowship, International Training (2012)

Network, BioChemLig OMCOS 16 IUPAC Poster Award (2011)

ADC Foundation Scholarship (2004-2008)

Preus Academic Scholarship (2004)

Selected Recent Publications

​Hyster, T. K. High-Valent Ni(II)- and Co(III)-Catalyzed C–H Activation Catal. Lett. 2015, 145, 458.

Hyster, T. K.; Farwell, C. C.; Buller, A. R.; McIntosh, J. A.; Arnold, F. H.* Enzyme-Controlled Nitrogen-atom Transfer Enables Regioselective C–H Amination J. Am. Chem. Soc. 2014, 136, 15505.

Hyster, T. K. “Di-tert-Butylcyclopentadiene” Electronic Encyclopedia of Reagents for Organic Synthesis, 2014.

Hyster, T. K.; Dalton, D. M.; Rovis, T.* Ligand Design for Rh(III)-Catalyzed C–H activation: An Unsymmetrical Cyclopentadienyl Group Enables a Regioselective Synthesis of Dihydroisoquinolones. Chem. Sci. 2015, 1, 254.

Hyster, T. K.; Arnold, F. H.* P450BM3-Axial Mutations: A Gateway to Non-Natural Reactivity Isr. J. Chem 2015, 55, 14.

Farwell, C. C.; McIntosh, J. A.; Hyster, T. K.; Wang, Z. J.; Arnold, F. H.* Enantioselective Imidation of Sulfides via Enzyme-Catalyzed Intermolecular Nitrogen-Atom Transfer J. Am. Chem. Soc. 2014, 136, 8766.

Davis, T. A.; Hyster, T. K.; Rovis, T.* Rh(III)-Catalyzed Intramolecular Hydroarylations, Amidoarylations, and Allylations: Three Pathways Determined by Amide Directing Group. Angew. Chem. Int. Ed. 2013, 52, 14181.

Hyster, T. K.; Knörr, L.; Rovis, T.*; Ward, T. R.*  Biotinylated Rh(III) Complex in Engineered Streptavidin for Rate Enhanced Asymmetric C-H Activation “Practical Methods in Biocatalysis and Biotransformations, In Press

Hyster, T. K.; Rovis, T.* Rh(III)-Catalyzed C–H Activation Mediated Synthesis of Isoquinolones from Amides and Cyclopropanes. SynLett. 2013, 24, 1842.

Hyster, T. K.; Ruhl, K. E.; Rovis, T.*  A Coupling of Benzamides and Donor/Acceptor Diazo Compounds To Form γ-Lactams via Rh(III)-Catalyzed C–H Activation. J. Am. Chem. Soc. 2013, 135, 5364.

Hyster, T. K.; Knörr, L.; Ward, T. R.*; Rovis, T.* Biotinylated Rh(III) Complex in Engineered Streptavidin for Rate Enhanced Asymmetric C-H Activation. Science, 2012 338, 500.

Hyster, T. K. “Ferrocenium Salts” Electronic Encyclopedia of Reagents for Organic Synthesis, 2012.

Du, Y.; Hyster, T. K.; Rovis, T.* Rhodium(III)-Catalyzed Oxidative Carbonylation of Benzamides with Carbon Monoxide. Chem. Commun. 2011, 47, 12074.

Hyster, T. K.; Rovis, T.* Pyridine Synthesis from Oximes and Alkynes via Rhodium (III) Catalysis: Cp* and Cpt Provide Complementary Selectivity. Chem. Commun. 2011, 47, 11846.

Hyster, T. K.; Rovis, T.* An Improved Catalyst Architecture for Rhodium (III) Catalyzed C−H Activation and its Application to Pyridone Syntheses. Chem. Sci. 2011, 2, 1606.

Hyster, T. K.; Rovis, T.* Rhodium-Catalyzed Oxidative Cycloaddition of Benzamides and Alkynes via C−H/N−H Activation. J. Am. Chem. Soc. 2010, 132, 10565.

Wentzel, M. T.; Reddy, V. J.; Hyster, T. K.; Douglas, C. J.* Chemoselectivity in Catalytic C−C and C−H Bond Activation: Controlling Intermolecular Carboacylation and Hydroarylation of Alkenes. Angew. Chem. Int. Ed. 2009, 48, 6121.