Publications

2014

Konnick, M.M.; Hashiguchi, B.G.; Devarajan, D.; Boaz, N.C.; Gunnoe, B.T.; Groves, J.T.; Ess, D.H.; Periana, R.A. Selective CH Oxy-Functionalization of Methane, Ethane and Propane by a Perfluoroarene Iodine (III) Complex, Angew. Chem. Int. Ed., 2014, in press

Groves, J.T.; Boaz, N.C. Fishing for the Peroxidase Protons, Science, 2014, in press

Groves, J.T. Enzymatic C-H Activation – Using Push to Get Pull, Nature Chemistry, 2014, 6, 89-91. [Full Text PDF]

O’Reilly, M.E.; Phals, D.R.; Webb, J.R.; Boaz, N.C.; Majumdar, S.; Hoff, C.D.; Groves, J.T.; Cundari, T.R.; Gunnoe, T.B. Reductive Functionalization of a Rhodium(III)-methyl Bond by Electronic Modification of the Supporting Ligand, Dalton Trans., 2014, 43(22), 8273-8281 [Full Text PDF]

Pahls, D.R.; Groves, J.T.; Gunnoe, B.T.; Cundari, T.R. Theoretical Study of Reductive Funcationalization of Methyl Ligands of Group 9 Complexes Supported by Two Bipyridyl Ligands: A Key Step in Catalytic Hydrocarbon Funcationalization, Organometallics, 2014, 33, 1936-1944. [Full Text PDF]

Huang, X.; Liu, W.; Ren, H.; Neelamegam, R.; Hooker, J.M.; Groves, J.T. Late Stage Benzylic C-H Fluorination with [18F] Fluoride for PET Imaging, J. Am. Chem. Soc., 2014, 136(19), 6842-6845  [Full Text PDF]

Fortman, G.C.; Boaz, N.C.; Konnick, M.M.; Periana, R.A.; Groves, J.T.; Gunnoe, B.T. Selective Mono-oxidation of Light Alkanes Using Chloride and Iodate, J. Am. Chem. Soc., 2014, 136(23), 8393-8401 [Full Text PD]

2013

Liu, W.; Huang, X., Groves, J.T. Oxidative Aliphatic C-H Fluorination with Manganese Catalysts and Fluoride Ion Nat. Protoc. 2013, 8 (12), 2348-2354. [Full Text PDF]

Bertrand, E.M.; Keddis, R.; Groves, J.T.; Vetriani, C.; Austin, R.N. Identity and Mechanisms of Alkane-oxidizing Metalloenzymes from Deep-sea Hydrothermal Vents Front. Microbiol. 2013, 4, 109.  [Full Text PDF]

Wang, D.; Groves, J.T. Efficient Water Oxidation Catalyzed by Homogeneous Cationic Cobalt Porphyrins with Critical Roles for the Buffer Base Proc. Nat. Acad. Sci. USA 2013, 39, 15579-15584. [Full Text PDF]

Wang, X.; Peter, S.; Ullrich, R.; Hofrichter, M.; Groves, J.T. Driving Force for Oxygen-Atom Transfer by Heme-Thiolate Enzymes  Agnew. Chem. Int. Ed. 2013, 52 (35), 9238-9241. [Full Text PDF]

Liu, W.; Groves, J.T. Mn-Catalyzed Oxidative Benzylic C-H Fluorination Using Fluoride Ion Angew. Chem. Int. Ed. 2013, 52 (23), 6024-6027 [Full Text PDF]

Bergstrom, C.L.; Beales, P.A.; Lv, Y.; Vanderlick, T.K.; Groves, J.T.  Cytochrome Causes Pore Formation in Cardiolipin-Containing Membranes Proc. Nat. Acad. Sci. U.S.A.2013, 110 (16), 6269-6274  [Full Text PDF]

Naing, S.-H.; Parvez, S.; Pender-Cudlip, M.; Groves, J.T.; Austin, R.N. Sustrate Specificity and Reaction Mechanism of Purified Alkane Hydroxylase from the Hydrocarbonoclastus Bacterium Alcanivorax Borkumensis (AbAlkB) J. Inorg. Biochem. 2013, 121, 46-52.  

2012

Cooper, H.L.R.; Mishra, G.; Huang, X.; Pender-Cudlip, M.; Austin, R.N.; Shanklin,J.; Groves, J.T. Parallel and Competitive Pathways for Substrate Desaturation, Hydroxylation and Radical Rearrangement by the Non-heme Diiron Hydroxylase AlkB J. Am. Chem. Soc. 2012, 134(50), 20365-20375 [Full Text PDF]

 Liu, W.; Huang, X.; Cheng, M.-J.; Nielsen, R.J.; Goddard, W.A., III; Groves, J.T. Oxidative Aliphatic C-H Fluorination with Fluoride Ion Catalyzed by a Manganese Porphyrin Science 2012, 337, 1322-1325 [Full Text PDF]

 Pouy, M.J.; Milczek, E.M.; Figg, T.M.; Otten, B. Flavin-Catalyzed Insertion of Oxygen into Rhenium-Methyl Bonds J. Am. Chem. Soc. 2012, 134(31), 12920-12923 [Full Text PDF]

 Wang, X.; Peter, S.; Kinne, M.; Hofrichter, M.; Groves, J.T. Detection and Kinetic Characterization of a Highly Reactive Heme-Thiolate Peroxygenase Compound I J. Am. Chem. Soc. 2012, 134, 12897-12900 [Full Text PDF]

 Szabo, G.; Loganathan, S.; Merkely, B.; Groves, J.T.; Karck, M.; Szabo, C.; Radovits, T. Catalytic Peroxynitrite Decomposition Improves Reperfusion Injury After Heart Transplantation J. Thorac Cardiovasc Surg 2012, 143(6), 1443-1449 [Full Text PDF]

Radovits, T.; Beller, C.J.; Groves, J.T.; Merkely, B.; Karck, M.; Szabo, C.; Szabo, G. Effects of FP15, a Peroxynitrite Decomposition Catalyst on Cardiac and Pulmonary Function After Cardiopulmonary Bypass Eur. J. Cardiothorac Surg 2012, 41, 391-396. [Full Text PDF]

2011

Umile, T.P., Groves, J.T. Dissection of the Mechanism of Manganese Porphyrin-Catalyzed Chlorine Dioxide Generation Inorg. Chem. 2011, 50(20), 10353-10362 [Full Text PDF]

Austin, R.N.; Groves, J.T. Alkane-oxidizing Metalloenzymes in the Carbon Cycle Metallomics 2011, 3, 751-854 [Full Text PDF]

Callaghan, A.V.; Morris, B.E.L.; Pereir, A.C.; McInerney, M.J.; Austin, R.N.; Groves, J.T.; Kukor, J.J.; Suflita, J.M.; Young, L.Y.; Zylstra, G.J.; Wawrik, B. The Genome Sequence of Desulfatibacillum alkenivorans AK-01: A Blueprint for Anaerobic Alkane Oxidation Environ. Microbiol. 2011, 44, 7287-7294 [Full Text PDF]

Golisz, S.R.; Gunnoe, T. B.; Goddard, III, W.A.; Groves, J.T.; Periana, R.A. Chemistry in the Center for Catalytic Hydrocarbon Functionalization: An Energy Frontier Research Center Catal. Lett. 2011, 2, 213-221 [Full Text PDF]

Beales, P.A.; Bergstrom, C.L.; Groves, J.T.; Vanderlick, T.K. Single Vesicle Observations of the Cardiolipin-Cytochrome c Interaction: Induction of Membrane Morphology Changes Langmuir 2011, 27, 6107-6115 [Full Text PDF]

Umile, T.; Groves, J.T. Catalytic Generation of Chlorine Dioxide from Chlorite Using a Water-soluble Manganese Porphyrin Angew. Chem. 2011, 50(3), 721-724 [Full Text PDF]

2010

Cooper, H.L.R..; Groves, J.T. Molecular Probes of the Mechanism of Cytochrome P450. Oxygen Traps a Substrate Radical Intermediate Arch. Biochem. Biophys. 2011, 507, 111-118. [Full Text PDF]

Surmeli, N.B..; Groves, Peroxynitrite Medidates Active Site Tyrosine Nitration in Manganese Superoxide Dismutase. Evidence of a Role for the Carbonate Radical Anion J. Am. Chem. Soc. 2010, 132, 17174-17185. [Full Text PDF]

Umile, T.; Groves, J.T. A “Push-Pull” Mechanism for Heterolytic O-O Bond Cleavage in Hydroperoxo Manganese Porphyrins Inorg. Chem. 2010, 24, 11516-11524 [Full Text PDF]

Su, J.; Groves, J.T. Mechanisms of Peroxynitrite Interactions with Heme Proteins Inorg. Chem. 2010, 49, 6317-6329 [Full Text PDF]

Liu, W.; Groves, J.T. Manganese Porphyrins Catalyze C-H Bond Halogenations J. Am. Chem. Soc. 2010, 132(37), 12847-12849. [Full Text PDF]

2009

Bell, S.; Groves, J.T. A Highly Reactive P450 Model Compound J. Am. Chem. Soc. 2009, 131(28), 9640-9641. (PMCID2760262) [Full Text PDF]

Su, J.; Groves, J.T. Direct Detection of the Oxygen Rebound Intermediates, Ferryl Mb and NO2 in the Reaction of met Myoglobin with Peroxynitrite J. Am. Chem. Soc. 2009, 131(36), 12979-12988. [Full Text PDF]

2008

Austin, R.N.; Luddy, K.; Erickson, K.; Pender-Cudlip, M.; Bertrand, E.; Deng, D.; Buzdygon, R.S.; van Beilen, J.B.; Groves, J.T.; Cage escape competes with geminate recombination during alkane hydroxylation by the diiron oxygenase AlkB. Angew. Chem. 2008, 47(28), 5232-5234. (PMID: 18512839) [Full Text PDF] [Abstract and TOC figure]

2007

Pavlov, I.; Vareniuk, I.; Drel, V.R.; Lyzogubov, V.; Ilnytska, O.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Obrosova, I. Nitrosative stress and neuropathy in mouse models of type 1 and type 2 diabetes. Diabetes 2007, 56, A207.

Obrosova, I.G.; Drel, V.R.; Oltman, C.L.; Mashtalir, N.; Tibrewala, J.; Groves, J.T.; Yorek, M.A. Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats. Am. J. Physiol. Endocrinol. Metab. 2007, 293(6) E1645-E1655. (PMID: 17911342) [Full Text PDF]

Drel, V.R.; Pacher, P.; Vareniuk, I.; Pavlov, I.; Ilnytska, O.; Lyzogubov, V.V.; Bell, S.R.; Groves, J.T.; Obrosova, I.G. Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetramesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes. International Journal of Molecular Medicine 2007, 20(6), 783-792. (PMCID2527588) [Full Text PDF]

Jin, N.; Ibrahim, M.; Spiro, T.G.; Groves, J.T. Trans-dioxo manganese(V) porphyrins. J. Am. Chem. Soc. 2007, 129(41), 12416. (Highlighted in Angew. Chem. Int. Ed. Engl. 2008, 47(15), 2737-9, The Groves-Spiro Dioxomanganese(v) Story). (PMCID2773832) [Full Text PDF] [Abstract and TOC figure]

Lahaye, D.; Groves, J.T. Modeling the haloperoxidases. Reversible oxygen atom transfer between bromide ion and an oxo-mn(V) porphyrin J. Inorg. Biochem. 2007, 101(11-12), 1786-1797. (PMID: 17825916) [Full Text PDF]

Drel, V.R.; Pacher, P.; Vareniuk, I.; Pavlov, I.; Ilnytska, O.; Lyzogubov, V.V.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice Eur. J. Pharmacol. 2007, 569(1-2), 48-58. (PMCID: PMC2225472) [Full Text PDF]

Chakrabarty, S.; Austin, R.N.; Deng, D.; Groves, J.T.; Lipscomb, J.D. Radical intermediates in monooxygenase reactions of rieske dioxygenase J. Am. Chem. Soc. 2007, 129(12), 3514-3515. (PMID: 17341076) [Full Text PDF]

Dismukes, G.C.; Hecht, M.; Spiro, T.G.; Groves, J.T.; Chianelli, R.R. Remembering Edward I. Stiefel J. Inorg. Biochem. 2007, 110, vii-viii. [Full Text PDF]

Vareniuk, I.; Pavlov, I.A.; Drel, V.R.; Lyzogubov, V.V.; Ilnytska, O.; Bell, S.R.; Tibrewala, J.; Groves, J.T.; Obrosova, I.G. Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice Exp. Neurol. 2007, 205, 425-436. DOI: 10.1016/j.expneurol.2007.03.019 [Full Text PDF]

Rozhkova-Novosad, E.A.; Chae, J.C.;
Zylstra, G.J.; Bertrand, E.M.; Deng, D.; Moe, L.; van Bielen, J.B.; Alexander-Ozinskas, M.; Danahy, M.; Groves, J.T.; Austin, R.N. Profiling mechanisms of alkane hydroxylase activity in vivo using the diagnostic substrate norcarane. Chem. Biol. 2007, 14, 165-172. [Full Text PDF]

Balakrishnan, G.; Hu, Y.; Oyerinde, O.F.; Su, J.; Groves, J.T.; Spiro, T.G. A conformational switch to ß-sheet structure in cytochrome c leads to heme exposure; implications for cardiolipin peroxidation and apoptosis. J. Am. Chem. Soc. 2007,
129(3), 504-505. (PMCID2596592) [Full Text PDF]

Radovits, T.; Seres, L.; Gerö, D.; Lin., L.; Beller, C.J.; Chen, S.-H.; Zotkina, J.; Berger, I.; Groves, J.T.; Szabó, C.; Szabó, G. The peroxynitrite decomposition catalyst FP15 improves ageing-associated cardiac and vascular dysfunction. Mechanisms of Ageing and Development 2007, 128(2), 173-181. [Full Text PDF]

2006

Morel, F.M.M.; Groves, J.T. Edward I. Stiefel (1942-2006) a Retrospective Science 2006, 314, 1406. [Full Text PDF]

Datta, A.; Quintavalla, S.M.; Groves, J.T. Kinetic selectivity in the N-alkylation of 2-pyridyl porphyrins: a facile approach to the α β β-scaffold. J. Org. Chem. 2006, 72(5), 1818-1821. DOI:10.1021/jo062017r. [Full Text PDF]

Austin, R.N.; Deng, D.; Jiang, Y.; Luddy, K.; van Beilen, J.B.; Ortiz de Montellano, P.R.; Groves, J.T. The diagnostic substrate bicyclohexane reveals a radical mechanism for bacterial cytochrome P450 in whole cells Angew. Chem. 2006, 45(48), 8192-8194. [Full Text PDF]

Groves, J.T. High-valent iron in chemical and biological oxidations. J. Inorg. Biochem. 2006, 100(4), 434-447. [Full Text PDF]

Wang, C.; Shalyaev, K.V.; Bonchio, M.; Carofiglio, T.; Groves, J.T. Fast catalytic hydroxylation of hydrocarbons with ruthenium porphyrins Inorg. Chem. 2006, 45(10), 4769-4782. [Full Text PDF]

DeAngelis, F.; Jin, N.; Car, R.; Groves, J.T. Electronic structure and reactivity of isomeric oxo-Mn(V) porphyrins: Effects of spin-state crossing and pK(a) modulation Inorg. Chem. 2006, 45(12), 4268-4276. [Full Text PDF]

Puranik, M.; Weeks, C.L.; Lahaye, D.; Kabil, O.; Taoka, S.; Nielsen, S.B.; Groves, J.T.; Banerjee, R.; Spiro, T.G. Dynamics of carbon monoxide binding to cystathionine β-synthase J. of Biol. Chem. 2006, 281(19), 13433-13438. [Full Text PDF]

Han, Y.-Z.; Sanford, M.S.; England, M.D.; Groves, J.T. Mechanistic studies of an unusual epoxide-forming elimination of a β-hydroxyalkyl rhodium porphyrin Chem. Commun. 2006, 5, 549-551. [Full Text PDF]

Luo, M.; Lin, H.; Fischbach, M.A.; Liu, D.R.; Walsh, C.T.; Groves, J.T. Enzymatic tailoring of enterobactin alters membrane partitioning and iron acquisition ACS Chem. Biol. 2006, 1(1), 29-32. [Full Text PDF]

2005

Obrosova, I.G.; Mabley, J.G.; Zsengellér, Z.; Charniauskaya, T.; Abatan, O.I.; Groves, J.T. Szabó, C. Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst The FASEB J. 2005, 19(3), 401-3. [Full Text PDF]

Luo, M.; Fadeev, E.A.; Groves, J.T. Membrane dynamics of the amiphiphilic siderophore, acinetoferrin J. Am. Chem. Soc., 2005, 127, 1726-1736. [Full Text PDF]

Fadeev, E.A.; Luo, M.; Groves, J.T. Synthesis and structural modeling of the amphiphilic siderophore rhizobactin-1021 and its analogs Bioorg. Med. Chem. Lett. 2005, 15, 3771-3774. [Full Text PDF]

Luo, M.; Fadeev, E.A.; Groves, J.T. Mycobactin-mediated iron acquisition within macrophages Nature Chem. Biol. 2005, 1, 149-153. [Full Text PDF]

Bertrand, E.; Sakai, R.; Rozhkova-Novosad, E.; Moe, L.; Fox, B.G.; Groves, J.T.; Austin, R.N. Reaction mechanisms of non-heme diiron hydroxylases characterized in whole cells J. Inorg. Biochem. 2005, 99(10), 1998-2006. [Full Text PDF]

Groves, J.T. Models and Mechanisms of Cytochrome P-450 Action In Cytochrome P450: Structure, Mechanism and Biochemistry; Ortiz de Montellano, P.R. Ed.; Kluwer Academic/Plenum Publishers: New York, 2005, pp. 1-44.

2004

Moe, L.A.; Hu, Z.; Deng, D.; Austin, R.N.; Groves, J.T.; Fox, B.G. Remarkable aliphatic hydroxylation by the diironenzyme toluene 4-monooxygenase in reactions with radical/cation diagnostic probes norcarane, 1, 1-dimethylcyclopropane, and 1,1-diethylcyclopropane Biochemistry 2004, 43, 15688-15701. [Full Text PDF]

Puranik, M.; Nielsen, S.B.; Youn, H.; Hvitved, A.N.; Bourassa, J.L.; Case, M.A.; Tengroth, C.; Balakrishnan, G.; Thorsteinsson, M.V.; Groves, J.T.; McLendon, G.L.; Roberts, G.P.; Olson, J.S.; Spiro, T.G. Dynamics of carbon monoxide binding to CooA J. Biol. Chem. 2004, 279, 21096-21108. [Full Text PDF]

Fadeev, E.A.; Luo, M.; Groves, J.T. Synthesis, structure and molecular dynamics of iron and gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin J. Am. Chem.Soc. 2004, 126(38), 12065-12075. [Full Text PDF]

Zhou, H.; Groves, J.T. Host-guest interactions of cyclodextrins and metalloporphyrins: Supramolecular building blocks toward artificial heme proteins J. Porphyrins Phthalocyanines 2004, 8, 125-140.

Sanford, M.S.; Groves, J.T. Ant-Markovnikov hydrofunctionalization of olefins mediated by rhodium porphyrins Angew. Chemie 2004, 116, 598-600. [Full Text PDF]

2003

Soriano, F.G.; Liaudet, L.; Mabley, J.G.; Salzman, A.L.; Groves, J.T.; Szabo C. Role of peroxynitrite in the pathogenesis of endotoxic and septic shock in rodents FASEB J. 2003, 17(5), A1069-A1070 Part 2 Suppl.

Pacher, P.; Liaudet, L.; Mabley, J.G.; Kaminski, P.M.; Virag, L.; Deb, A.; Ungvari, Z.; Wolin, M.S.; Groves, J.T.; Szabo, C. Role of superoxide, NO and peroxynitrite in doxorubicin-induced cardiac dysfunction FASEB J. 2003, 17(4), A229-A229 Part 1 Suppl.

Naidu, B.V.; Farivar, A.S.; Woolley, S.M.; Fraga, C.; Salzman, A.L.; Szabo, C.; Groves, J.T.; Mulligan, M.S. Enhanced peroxynitrite decomposition protects against experimental obliterative bronchiolitis Exp. Mol. Pathol. 2003, 75(1), 12-17. [Full Text PDF]

Phillips-McNaughton, K.; Groves, J.T. Zinc-Coordination oligomers of phenanthrolinylporphyrins Org. Lett. 2003, 5(11), 1829-1832. [Full Text PDF]

Austin, R.N.; Buzzi, K.; Kim, E.; Zylstra, G.J.; Groves, J.T. Xylene monooxygenase, a membrane-spanning non-heme diiron enzyme that hydroxylates hydrocarbons via a substrate radical intermediate
J. Biol. Inorg. Chem. 2003, 8, 733-739. [Full Text PDF]

Pacher, P.; Liaudet, L.; Bai, P.; Mabley, J.G.; Kaminsk, P.M.; Virág, L.; Deb, A.; Szabó, E.; Ungvári, Z.; Wolin, M.S.; Groves, J.T.; Szabó, C. A potent peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction Circulation 2003, 107,(6), 896-904. [Full Text PDF]

Groves, J.T. The bioinorganic chemistry of iron in Oxygenases and supramolecular assemblies Proc. Nat. Acad. Sci. U.S.A. 2003, 100, 3569-3574. [Full Text PDF]

2002

Mabley, J.G.; Liaudet, L.; Pacher, P.; Southan, G.; Groves, J.T.; Salzman, A.L.; Szabó, C. Beneficial effects of the peroxynitrite decomposition catalyst FP15 in murine models of arthritis and colitis
Molecular Medicine 2002, 8(10), 581-590. [Full Text PDF]

Szabo, C.; Mabley, J.G.; Moeller, S.M.; Shimanovich, R.; Pacher, P.; Virag, L.; Soriano, F.G.; Van Duzer, J.H.; Williams, W.; Salzman, A.L.; Groves, J.T. Pathogenicrole of peroxynitrite in the development of diabetes and diabetic vascular complications: Studies with FP15, a novel, potent peroxynitrite decomposition catalyst Molecular Medicine 2002, 8(10), 571-–580 [Full Text PDF]

Szabo, C.; Mabley, J.G.; Moeller, S.M.; Shimanovich, R.; Groves, J.T. FP 15, a novel, potent peroxynitrite decomposition catalyst: in vitro cytoprotective actions and protection against diabetes mellitus and diabetic cardiovascular complications FASEB J. 2002, 16, A1166.

Groves, J.T.; Moeller, S. Peroxynitrite decomposition catalysts and methods of use thereof. U.S. Patent 6,448,239, 2002.

Xu, G.; Martinez, J.; Groves, J.T.; Butler, A. Membrane affinity of the amphiphilic marinobactin siderophores J. Am. Chem. Soc. 2002, 124(45), 13408-13415.[Full Text PDF]

Auclair, K.; Hu, Z.; Little, D.M.; Ortiz de Montellano, P.R.; Groves, J.T. Revisiting the mechanism of P450 enzymes using the radical clocks norcarane and Spiro[2,5]octane J. Am. Chem Soc. 2002, 124, 6020-6027. [Full Text PDF]

Sauve, A.A.; Groves, J.T. Synthesis of trithiolanes and tetrathianes from thiiranes catalyzed by ruthenium salen nitrosyl complexes J. Am. Chem. Soc. 2002, 124, 4770-4778. [Full Text PDF]

2001

Brazeau, B.J.; Austin, R.N.; Tarr, C.; Groves, J.T.; Lipscomb, J.D. Intermediate Q from soluble methane monooxygenase hydroxylates the mechanistic substrate probe norcarane: Evidence for a stepwise reaction J. Am. Chem. Soc. 2001, 123, 11831-11837. [Full Text PDF]

Groves, J.T.; Austin, R.N.; Chang, H.K.; Zylstra, G.J. The non-heme diiron alkane monooxygenase of Pseudomonas oleovorans (AlkB) hydroxylates via a substrate radical intermediate J. Inorg. Biochem. 2001, 86, 54-54.

Ogliaro, F.; de Visser, S.P.; Groves, J.T.; Shaik, S. Chameleon states: High-valent metal-oxo species of cytochrome P450 and its ruthenium analog Angew. Chem. 2001, 40, 2874-2878.

Bourassa, J.L.; Ives, E.P.; Marqueling, A.L.; Shimanovich, R.; Groves, J.T. Myoglobin catalyzes its own nitration J. Am. Chem. Soc., 2001, 123, 5142-3. [Full Text PDF]

McMahon, B.; Frauenfelder, H.; Austin, R.; Chu, K.; Groves, J.T. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin Biophys. J. 2001, 286a. [Full Text PDF]

Xu, G.; Wang, W.; Groves, J.T.; Hecht, M.H. Continuous thin films of protein β-sheets from a combinatorial library. Proc. Nat. Acad. Sci. U.S.A 2001, 98, 3652-57. [Full Text PDF]

Frauenfelder, H.; McMahon, B.H.; Austin, R.A.; Chu, K.; Groves, J.T. The role of structure, energy landscape, dynamics, and allostery in the enzymatic function of myoglobin. Proc. Nat. Acad. Sci. U.S.A. 2001, 98, 2370-2374. [Full Text PDF]

Shimanovich, R.; Groves, J.T. Mechanisms of peroxynitrite decomposition catalyzed by FeTMPS, a bioactive sulfonated iron porphyrin. Arch. Biochem. Biophys. 2001, 387, 307-317. [Full Text PDF]

Shimanovich, R.; Niezgoda, S.; Lynch, V.; Gerasimchuk, N.N.; Mody, T.; Magda, D.; Sessler, J.; Groves, J.T. Mn(II)-Texaphyrin as a catalyst for the decomposition of peroxynitrite. J. Am. Chem. Soc. 2001, 123, 3613-3614. [Full Text PDF]

Xu, G.; Aksay, I.A.; Groves, J.T. Continuous crystalline dahllite thin films via inhibited template assembly. J. Am. Chem. Soc. 2001, 123, 2196-2203. [Full Text PDF]

2000

Austin, R.N.; Chang, H.-K.; Zylstra, G.J.; Groves, J.T. The non-heme diiron alkane monooxygenase of pseudomonas oleovorans (AlkB) hydroxylates via a substrate radical intermediate. J. Am. Chem. Soc. 2000, 122, 11747-11748. [Full Text PDF]

Jin, N.; Bourassa, J.L.; Tizio, S.C.; Groves, J.T. Rapid, reversible oxygen atom transfer between an oxomanganese(V) porphyrin and bromide. A haloperoxidase mimic with enzymatic rates. Angew. Chem. 2000, 39, 3849-3851.

Groves, J.T.; Wang, C.C.-Y. Nitric oxide synthase: models and mechanisms. Curr. Opinion in Chem. Biol. 2000, 4, 687-695. [Full Text PDF]

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. An amorphous to crystalline transition in the formation of CaCO3 thin films. Proc. Microsc. Microanal., 2000, 6 Suppl. [2], 1072-73.

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. Synthesis of CaCO3 thin films via a bioinspired pathway: Cooperative template-inhibition. Proc. Microsc. Microanal. 2000, 6 Suppl. [2], 1070-71.

Groves, J.T. Reactivity and mechanisms of oxometalloporphyrin-catalyzed oxidations. J. Porphyrins Phthalocyanines2000, 4, 350-352. [Full Text PDF]

Xu, G.; Bao, Z.; Groves, J.T. Langmuir-Blodgett films of regioregular Poly(3-hexylthiophene) as field-effect transistors. Langmuir 2000, 16, 1834-41. [Full Text PDF]

1999

Groves, J.T.; Lee, J.; Hunt, J.A.; Shimanovich, R.; Jin, N.; Mechanisms of metalloporphyrin reactions with peroxynitrite. J. Inorg. Biochem. 1999, 74, 28.

Wang, C.C.-Y.; Ho, D.M.; Groves, J.T. Models of nitric oxide synthase: Iron(III)porphyrin-catalyzed oxidation of fluorenone oxime to nitric oxide and fluorenone. J. Am. Chem. Soc. 1999, 121, 12094-12103. [Full Text PDF]

Groves, J.T.; Carofiglio, T.; Bonchio, M.; Sauve, A. Catalytic oxygenation of hydrocarbons by metalloporphyrin and metallosalen complexes. U.S. Patent US1996000760849, 1999

Groves, J.T.; Shalyaev, K.; Lee, J. Oxometalloporphyrins in Oxidative Catalysis. In The Porphyrin Handbook; Kadish, K.M., Smith, K.M., Guilard, R., Eds.; Academic Press: San Diego, CA and Burlington, MA, 1999, Vol. 4, Ch. 27, pp 17-40.

Groves, J.T. Peroxynitrite: Reactive, invasive and enigmatic. Curr. Opinion in Chem. Biol. 1999, 3, 226-235. [Full Text PDF]

Jin, N.; Groves, J.T. Unusual kinetic stability of a ground sate singlet oxomanganese(V) porphyrin. Evidence for a spin state crossing effect. J. Am. Chem. Soc. 1999, 121, 2923-2924. [Full Text PDF]

1998

Xu, G.; Yao, N.; Aksay, I.A.; Groves, J.T. Biomimetic synthesis of macroscopic scale calcium carbonate thin films. Evidence for a multistep process. J. Am. Chem. Soc. 1998, 120, 11977-11985.

McLain, J.; Lee, J.; Groves, J.T. Biomimetic Oxygenations Related to Cytochrome P450. Metal-oxo and Metal-peroxo Intermediates. In Biomimetic Oxidations, Meunier, B., Ed.; ICP Publishers: 1999, Ch. 3. pp 91-170.

Lee, J.; Hunt, J.A.; Groves, J.T. Mechanisms of iron porphyrin reactions with peroxynitrite. J. Am. Chem. Soc. 1998, 120, 7493-7501.

Lee, J.; Hunt, J.A.; Groves, J.T. Manganese porphyrins as redox-coupled peroxynitrite reductases. J. Am. Chem. Soc. 1998, 120, 6053-61.

Groves, J.T.; Crowley, S.J.; Shalyaev, K.V. Paramagnetic 1H-NMR relaxation probes of stereoselectivity in metalloporphyrin catalyzed olefin epoxidation. Chirality 1998, 10, 106-119.

1997

Marla, S.S.; Lee, J.; Groves, J.T. Peroxynitrite rapidly permeates phospholipid membranes. Proc. Nat. Acad. Sci. U.S.A. 1997, 94, 14243.

Lee, J.; Hunt, J.A.; Groves, J.T. Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox-couples. Bioorg. Med. Chem. Lett. 1997, 7, 2913-18.

Hunt, J.A.; Lee, J.; Groves, J.T. Amphiphilic peroxynitrite decomposition catalysts in liposomal assemblies. Chemistry and Biology 1997,, 4, 845-858.

Groves, J.T.; Wang, C.Y.; Models for nitric oxide synthase. FASEB J. 1997, 11, A769.

Groves, J.T. Artificial enzymes: The importance of being selective. Nature 1997,, 389, 329-330.

Groves, J.T.; Shalyaev, K.V.; Bonchio, M.; Carofiglio, T. Rapid Catalytic Oxygenation of Hydrocarbons with Perhalogenated Ruthenium Porphyrin Complexes. In Studies in Surface Science and Catalysis; Proceedings of the Third World Congress on Oxidation Catalysis, San Diego, CA, 1997; Grasselli, R.K., Oyama, S.T., Gafney, A.M., Lyons, J.E., Eds.; Elsevier: Amsterdam, 1997, Vol. 110, 865-872.

Groves, J.T.; Lee, J.; Marla, S. Detection and characterization of an oxo-anganese(V) porphyrin complex by rapid-mixing stopped-flow spectrophotometry. J. Am. Chem. Soc. 1997, 119, 6269-6273.

Lahiri, J.; Xu, G.; Dabbs, D.M.; Yao, N.; Aksay, I.A.; Groves, J.T. Designed amphiphilic porphyrin templates for the oriented nucleation of calcium carbonate. J. Am. Chem. Soc. 1997, 119, 5449-50.

1996

Groves, J.T. Multi-heme self-assembly and electron transfer in phospholipid vesicles. Photochem. Photobiol. 1996, 63, 21.

Groves, J.T.; Matsunaga, A. Designed double strand cleavage of DNA by metalloporphyrins. Bioorg. Med. Chem. Lett. 1996, 6, 1595-1600.

Lahiri, J.; Xu, G.; Lee, T.; Dabbs, D.M.; Yao, N.; Aksay, I.A.; Groves, J.T. Biomimetic Fabrication of Materials – The Minimalist Approach. In Smart Materials Technologies and Biomimetics, Proceedings of the International Society for Optical Engineering, San Diego, CA, 1996; Crowson, A., Ed.;
Vol. 2716, 317-323.

Aksay, I.A.; Groves, J.T.; Gruner, S.M.; Lee, P.C.Y.; Prud’homme, R.K.; Shih, W.-H.; Torquato, S.; Whitesides, G.J. Smart Materials Systems Through Mesoscale Patterning. In Smart Materials Technologies and Biomimetics, Proceedings of the International Society for Optical Engineering, San Diego, CA, 1996; Crowson, A., Ed.; Vol. 2716, 280-288.

Baum, E.Z.; Ding, W.-D.; Siegel, M.M.; Hulmes, J.; Bebernitz, G.A.; Sridharan, L.; Tabei, K.; Krishnamurthy, G.; Carofiglio, T.; Groves, J.T.; Bloom, J.D.; DiGrandi, M.; Bradley, M.; Ellestad, G.; Seddon, A.P.; Gluzman, Y. Flavins inhibit human cytomegalovirus UL80 protease via disulfide bond formation. Biochemistry 1996, 35, 5847-55.

Groves, J.T.; Bonchio, M.; Carofiglio, T. Rapid catalytic oxygenation of hydrocarbons by ruthenium porphyrin complexes. J. Am. Chem. Soc. 1996, 118, 8961.

Lahiri, J.; Fate, G.D.; Ungashe, S.; Groves, J.T. Multi-heme self-assembly in phospholipid vesicles. J. Am. Chem. Soc. 1996, 118, 2347-2358.

1995

Groves, J.T.; Marla, S. Peroxynitrite-induced DNA strand scission mediated by a manganese porphyrin. J. Am. Chem. Soc. 1995, 117, 9578.

Groves, J.T.; Roman, J.S. Nitrous oxide activation by a ruthenium porphyrin. J. Am. Chem. Soc. 1995, 117, 5594.

Groves, J.T.; Han, Y.-Z. Models and Mechanisms of Cytochrome P-450 Action. In Cytochrome P-450, 2nd ed.; Ortiz De Montellano, P., Ed.; 1995; pp 1-45.

Groves, J.T.; Gross, Z. On the Mechanism of Epoxidation and Hydroxylation Catalyzed by Iron Porphyrins. Evidence for Non-Intersecting Reaction Pathways. In Bioinorganic Chemistry: An Inorganic Perspective of Life; Kessissoglou, D.P., Ed.; NATO ASI Series 459;
Kluwer Academic Publishers: Dordrecht, 1995; pp 39-47.

Kim, R.M.; Fate, G.D.; Gonzáles, J.E.; Lahiri, J.; Ungashe, S.B.;
Groves, J.T. Self-assembly, Catalysis and Electron Transfer with Metalloporphyrins in Phospholipid Membranes. In Bioinorganic Chemistry: An Inorganic Perspective of Life; NATO ASI Series, 459; Kessissoglou, D.P., Ed.; Kluwer Academic Publishers: Dordrecht, 1995; pp 49-56.

1994

Ahn, K.-H.; Groves, J.T. Shape selective oxygen transfer to olefins catalyzed by sterically hindered iron porphyrins. Bull. Korean Chem. Soc. 1994, 15(11), 957-961.

Choma, C.T.; Kaestle, K.; Kim, R.M.; Åkerfeldt, K.S.; Groves, J.T.; DeGrado, W.F. A general method for coupling unprotected peptides to bromoacetamido porphyrin templates. Tetrahedron Lett. 1994, 35(34), 6191.

Groves, J.T.; Fate, G.; Lahiri, J. Directed multi-heme-self-assembly and electron transfer in a model membrane. J. Am. Chem. Soc. 1994, 116, 5477-5478.

Groves, J.T.; Gross, Z. Preparation and reactivity of oxoiron(IV) porphyrins. Inorg. Chem. 1994, 33, 5065-5072.

1993

Kim, R.M.; Pillon, J.E.; Burwell, D.A.; Groves, J.T.; Thompson, M.E. Intercalation of aminophenyl-and pyridinium-substituted porphyrins into zirconium hydrogen phosphate: Evidence for substituent-derived orientational selectivity. Inorg. Chem. 1993, 32, 4509- 4516.

Kady, I.O.; Groves, J.T. Synthesis of iron-binding oligonucleotides and their reactions with single-stranded DNA. Bioorg. Med. Chem. Lett. 1993, 3(6), 1367-1370.

Groves, J.T.; Kady, I.O. Sequence-specific cleavage of DNA by oligonucleotide-bound metal complexes. Inorg. Chem. 1993, 32, 3868-3872.

Ungashe, S.B.; Groves, J.T. Porphyrins and metalloporphyrins in synthetic bilayer membranes. In Advances in Inorganic Biochemistry, Marzilli, L.G., Ed.; Academic Press: 1993; Vol. 9, pp. 318-351.