PROFILING TO DISCOVER ENDOGENOUS BIOACTIVE MOLECULES
Advances in mass spectrometry profiling enable deeper analysis of biomolecules and when coupled with interesting biological samples or questions can lead to the discovery of new molecules. In particular, the application of profiling methods to models of type 2 diabetes has led to the detection of a novel class of lipids with potent anti-diabetic and anti-inflammatory properties. Likewise, the use of similar approaches to study mammalian peptides has revealed a large family of non-annotated miniproteins with various cell biological functions. Together these examples highlight the power of analytical chemistry when integrated with biology to reveal novel bioactive molecules.