Contact
Faculty Assistant

Jon Darmon
Coordinating Editor and Lab Manager
jdarmon@princeton.edu
Frick Laboratory, 289
609-258-4883

Research Focus

Paul Chirik video interviewCatalysis is at the core of sustainable chemistry. Many catalytic processes, however, rely on elements that are expensive, in short supply or have a significant environmental footprint associated with their extraction and isolation. The Chirik group is exploring “modern alchemy” for sustainable chemistry – a concept defined as using ligand design to transmute the function of an earth abundant metal to mimic or ideally surpass the performance of more exotic precious elements.

Our approach is multidisciplinary, spanning the traditional areas of organic and inorganic chemistry. At the core of our work is understanding and manipulating electron flow in first row transition metal compounds. We integrate modern spectroscopic and theoretical methods to accomplish these objectives. In one limit, oxidation and reduction chemistry occurs cooperatively between the metal and the supporting ligand. This concept of “redox active” ligands has resulted in new base metal catalysts for the asymmetric hydrogenation of alkenes as well as the hydrosilylation and hydroboration of olefins.

In each case, the base metal catalysts offer unique function over established precious metals catalysts.

Our catalyst development efforts are often paired with industrial partners as our catalysts find relevance to problems in the pharmaceutical, flavor and fragrance, petrochemical and silicones industries. In chemistry unique to these electronic structures, we have also discovered unprecedented cycloaddition reactions that overcome the constraints of orbital symmetry and enable a new, thermal route to various cyclobutane derivatives. The applications of these methods to various synthetic targets are under investigation.

An alternative approach is confining redox changes to the base metal. In this so-called strong field limit, the base metal catalysts are sufficiently electron rich to enable the activation and functionalization of ubiquitous but otherwise kinetically inert C-H bonds. A general, cobalt-catalyzed method for C-H borylation has been discovered with distinct advantages over existing precious metal catalysts. The application of this process to various synthetic challenges are currently under investigation. More broadly, our group actively explores how manipulation of electronic structure can be applied to new problems in catalysis.

The two major areas of study in our laboratory are in Base Metal Catalysis and N2 Functionalization

A second area of long-standing interest is the fixation of molecular nitrogen, N2. While the industrial Haber-Bosch process has had a transformative impact on society – enabling food production for approximately half of the world’s population and accounting for half of the nitrogen in the body – the fossil fuel inputs and carbon footprint associated with this reaction inspire the search for alternatives. Our laboratory is developing new routes to N-H and N-C bond forming reactions using molecular nitrogen as the building block. If successful, these methods would either circumvent the Haber-Bosch process or result in ammonia synthesis methods that are compatible with renewable hydrogen. To accomplish these objectives, we study early transition metal complexes that by virtue of their designed coordination environment, activate or even cleave the strong NN bond in N2. One particularly notable process is ligand-induced N2 bond cleavage, where various ureas, oxamides, formates and amines have been synthesized from N2 and CO – diatomic molecules with the two strongest bonds in chemistry.

Research Areas
Catalysis / Synthesis
Inorganic Chemistry
Honors

US EPA Presidential Green Chemistry Challenge Award (2016)

Nankai-Asymchem Lecture (2016)

Editor-in-Chief, Organometallics (2015)

First Japanese Society of Coordination Chemistry Award for Creative Work (2015)

Xingda Lecture, Peking University (2015)

Closs Lecturer, University of Chicago (2014)

Dalton Lecturer of the Royal Society of Chemistry (2011)

Defense Science Study Group (2010-2011)

Blavatnik Award, New York Academy of Sciences (2009)

Arthur C. Cope Scholar Award, American Chemical Society (2009)

Bessel Fellow of the Alexander von Humboldt Foundation (2008)

Camille Dreyfus-Teacher Scholar (2006)

Stephen and Margery Russell Distinguished Teaching Award (2005)

Cottrell Scholar, Research Corporation (2004)

David and Lucile Packard Fellow in Science and Engineering (2004)

NSF CAREER Award (2003)

Selected Recent Publications

Earth Abundant Metal Catalysts

Friedfeld, M. R.; Zhong, H.; Ruck, R. T.; Shevlin, M.; Chirik, P. J. “Cobalt-catalyzed asymmetric hydrogenation of enamides enabled by single-electron reduction.” Science2018360, 888-893.

Schmidt, V. A.; Kennedy, C. R.; Bezdek, M. J.; Chirik, P. J. “Selective [1,4]-hydrovinylation of 1,3-dienes with unactivated olefins enabled by iron diimine catalysts.” J. Am. Chem. Soc. 2018140, 3443-3453.

Krautwald, S.; Bezdek, M. J.; Chirik, P. J. “Cobalt-catalyzed 1,1-diboration of terminal alkynes: Scope, mechanism and synthetic applications.” J. Am. Chem. Soc. 2017139, 3868-3875.

Yu, R. P.; Hesk, D.; Rivera, N.; Pelczer, I.; Chirik, P. J. “Iron-catalyzed tritiation of pharmaceuticals.” Nature 2016529, 195-199.

Neely, J. M.; Bezdek, M. J.; Chirik, P. J. “Insight into transmetalation enables cobat-catalyzed Suzuki-Miyaura coupling.” ACS Central Science 20162, 935-942.

Hoyt, J. M.; Schmidt, V. A.; Tondreau, A. M.; Chirik, P. J.  “Iron-catalyzed intermolecular [2+2] cycloadditions of unactivated alkenes.” Science 2015349, 960-963.

 

Ammonia Chemistry

Rafiq, S.; Bezdek, M. J.; Koch, M; Chirik, P. J.; Scholes, G. D. “Ulfrafast photophysics of a dinitrogen bridged molybdenum complex.” J. Am. Chem. Soc. 2018140, 6298-6307.

Bezdek, M. J.; Chirik, P. J. “Intercoversion of molybdenum imido and amido complexes by proton coupled electron transfer.” Angew. Chem. Int. Ed.201857, 2224-2228.

Margulieux, G. W.; Bezdek, M. J.; Turner, Z. R.; Chirik, P. J. “Ammonia activation, H2evolution, and nitride formation from a molybdenum complex.” J. Am. Chem. Soc. 2017139, 6110-6113.

Bezdek, M.; Guo, S.; Chirik, P. J. “Coordination induced bond weakening of ammonia, water, and hydrazine with a molybdenum complex.” Science 2016354, 730-733.