Frick Laboratory, 257
I. Theoretical Research: At the molecular scale, quantum dynamics provides the proper perspective to describe evolving chemical and physical processes. A central component of our research concerns the active control of such processes through the introduction of suitable shaped laser pulses, and this theoretical activity is tightly linked with the laboratory program below. In recent years, quantum dynamics has moved from the domain of studying natural processes to the active realm of introducing external laser pulses for manipulating the dynamics at will. Our theoretical research in this area is exploring the principles of controlling quantum phenomena and developing the algorithms to guide the ensuing experiments. The theme of controlling events at the molecular scale also extends to our research in systems biology. Studies in this area involve the development of analysis tools to identify the key linkages in complex bionetworks to reveal how they function as well as how to control them through the introduction of tailored chemicals. This research direction has also opened up the development of novel algorithms to accelerate laboratory synthesis and discovery with efficacious molecules including pharmaceuticals. All aspects of our theoretical research are linked through a systems perspective viewing chemical, materials, and biological transformations as high dimensional multivariable problems for analysis in optimization.
II. Experimental Research: The primary laboratory component of our research is in the area of controlling quantum dynamics phenomena using shaped ultrafast laser pulses. The laboratory operates with three state-of-the-art femtosecond laser systems having the ability to perform high throughput experiments with the shaped laser pulses acting as “photonic reagents” to strongly interact with molecular and condensed phase samples. These interactions can alter the pathway of quantum dynamics phenomena as well as permanently change the state of the matter including for selective molecular bond breaking and rearrangement. These laboratory studies are tightly linked to our associated theoretical research with the overall goal of revealing the fundamental principles for controlling quantum phenomena, including the control of individual molecules as well as bulk samples. Applications are also being pursued in the area of creating advanced molecular and biological detectors and ultrafast molecular switches. As with the theoretical research, an allied program of laboratory systems biology is also part of our studies. In this case, experiments are being carried out collaboratively at Princeton as well as with other groups in the U.S. and abroad. A special area of biological focus includes identifying key steps in metabolism and the engineering of bacteria and algae to optimize their production of biofuels. Algorithms ensuing from the theoretical research guide all aspects of our laboratory research, and the experimental findings are fed back to further foster the theoretical studies.
The Rabitz group conducts theoretical and experimental research in broad areas of physical chemistry with a special focus on laser control of molecular dynamics phenomena. In addition, theoretical research is underway in systems biology to provide algorithms for the analysis of bionetworks and to guide experiments for the re-engineering of such networks and their functions.
Alexander von Humboldt Award (2014)
Honorary member of the International Physics and Control Society (IPACS) (2006)
Fellow of the American Association for the Advancement of Science (2004)
Genetic and Evolutionary Computation Gold Award (2004)
Willis E. Lamb Medal for Laser Science and Quantum Optics (2003)
Alexander von Humboldt Award (2000)
Charles Phelps Smyth Professor of Chemistry (2000)
Alfred P. Sloan Fellow (1975–1979)
Camille and Henry Dreyfus Teacher-Scholar (1974–1979)
Paskover, Y.; Xie, D.; Laforge, F. O.; Rabitz, H., "Selectively addressing optically nonlinear nanocrystals by polarization-shaped ultrafast laser pulses." Journal of the Optical Society of America B-Optical Physics 2014, 31 (5), 1165-1173.
Donovan, A.; Beltrani, V.; Rabitz, H., "Local topology at limited resource induced suboptimal traps on the quantum control landscape." Journal of Mathematical Chemistry 2014, 52 (2), 407-429.
Gao, F.; Rey-de-Castro, R.; Donovan, A. M.; Xu, J.; Wang, Y.; Rabitz, H.; Shuang, F., "Pathway dynamics in the optimal quantum control of rubidium: Cooperation and competition." Physical Review A 2014, 89 (2).
Chen, C.; Dong, D.; Long, R.; Petersen, I. R.; Rabitz, H. A., "Sampling-based learning control of inhomogeneous quantum ensembles." Physical Review A 2014, 89 (2).
Sun, Q.; Pelczer, I.; Riviello, G.; Wu, R.-B.; Rabitz, H., "Experimental exploration over a quantum control landscape through nuclear magnetic resonance." Physical Review A 2014, 89 (3).
de Lima, E. F.; Ho, T.-S.; Rabitz, H., "Invariance of quantum optimal control fields to experimental parameters." Physical Review A 2014, 89 (4).
Shabani, A.; Mohseni, M.; Rabitz, H.; Lloyd, S., "Numerical evidence for robustness of environment-assisted quantum transport." Physical Review E 2014, 89 (4).
Roslund, J.; Rabitz, H., "Dynamic Dimensionality Identification for Quantum Control." Physical Review Letters 2014, 112 (14).
Mohseni, M.; Shabani, A.; Lloyd, S.; Rabitz, H., "Energy-scales convergence for optimal and robust quantum transport in photosynthetic complexes." Journal of Chemical Physics 2014, 140 (3).
Tibbetts, K. M.; Xing, X.; Rabitz, H., "Laboratory transferability of optimally shaped laser pulses for quantum control." Journal of Chemical Physics 2014, 140 (7).
Kurosaki, Y.; Ho, T.-S.; Rabitz, H., "Quantum optimal control pathways of ozone isomerization dynamics subject to competing dissociation: A two-state one-dimensional model." Journal of Chemical Physics 2014, 140 (8).
Zhang, W.; Shu, C.-C.; Ho, T.-S.; Rabitz, H.; Cong, S.-L., "Optimal control of charge transfer for slow H+ + D collisions with shaped laser pulses." Journal of Chemical Physics 2014, 140 (9).
Bergasa-Caceres, F.; Rabitz, H. A., "Flexibility damps macromolecular crowding effects on protein folding dynamics: Application to the murine prion protein (121-231)." Chemical Physics Letters 2014, 591, 207-211.
Li, G.; Rabitz, H., "Analysis of gene network robustness based on saturated fixed point attractors." EURASIP journal on bioinformatics & systems biology 2014, 2014 (1), 4-4.
Hsu, L.-Y.; Li, E. Y.; Rabitz, H., "Single-Molecule Electric Revolving Door." Nano Letters 2013, 13 (11), 5020-5025.
Rey-de-Castro, R.; Cabrera, R.; Bondar, D. I.; Rabitz, H., "Time-resolved quantum process tomography using Hamiltonian-encoding and observable-decoding." New Journal of Physics 2013, 15.
Tibbetts, K. M.; Xing, X.; Rabitz, H., "Optimal control of molecular fragmentation with homologous families of photonic reagents and chemical substrates." Physical Chemistry Chemical Physics 2013, 15 (41), 18012-18022.
Moore Tibbetts, K.; Xing, X.; Rabitz, H., "Optimal control of molecular fragmentation with homologous families of photonic reagents and chemical substrates." Physical chemistry chemical physics : PCCP 2013, 15 (41), 18012-22.
Long, R.; Riviello, G.; Rabitz, H., "The Gradient Flow for Control of Closed Quantum Systems." Ieee Transactions on Automatic Control 2013, 58 (10), 2665-2669.
Yang, F.; Cong, S.; Long, R.; Ho, T.-S.; Wu, R.; Rabitz, H., "Exploring the transition-probability-control landscape of open quantum systems: Application to a two-level case." Physical Review A 2013, 88 (3).
Rey-de-Castro, R.; Leghtas, Z.; Rabitz, H., "Manipulating Quantum Pathways on the Fly." Physical Review Letters 2013, 110 (22).
Tibbetts, K. M.; Xing, X.; Rabitz, H., "Systematic Trends in Photonic Reagent Induced Reactions in a Homologous Chemical Family." Journal of Physical Chemistry A 2013, 117 (34), 8205-8215.
Tibbetts, K. M.; Xing, X.; Rabitz, H., "Exploring control landscapes for laser-driven molecular fragmentation." Journal of Chemical Physics 2013, 139 (14).
Tibbetts, K. W. M.; Li, R.; Pelczer, I.; "Rabitz, H., Discovering predictive rules of chemistry from property landscapes." Chemical Physics Letters 2013, 572, 1-12.