New amination chemistry brought to light | Chemical & Engineering News
By Tien Nguyen, Department of Chemistry
Monday, Feb. 20, 2017
Chemists in the Knowles lab at Princeton University and Bristol-Myers Squibb have developed a new light-catalyzed reaction that provides unique access to biologically relevant amines. Published in Science, the work was highlighted in an article on Chemical and Engineering News:
"The new hydroamination is noteworthy for its intermolecular reactivity, its use of unactivated olefin substrates, its toleration of several different functional groups, and its regioselectivity for anti-Markovnikov amine products—wherein the new C–N bond forms on the less substituted carbon of the olefin. Most other examples of hydroaminations result in products with the opposite, Markovnikov regiochemistry. What’s more, the new reaction can produce highly substituted amines (such as in the example shown) that are impossible to make any other way."