Bill Morandi

Department of Chemistry and Applied Biosciences
ETH Zurich

Thursday, Feb. 7, 2019 4:30pm
Edward C Taylor Auditorium, Frick B02
Abigail Doyle
Add to Calendar2019-02-07 16:30:002019-02-07 16:30:00Abigail DoyleEdward C Taylor Auditorium, Frick B0215YYYY-MM-DD

Shuttle Catalysis – a Conceptual Blueprint for Reversible Functional Group Transfer

Catalytic reversible reactions, such as alkene metathesis and transfer hydrogenation, have had an auspicious impact on the molecular sciences. This presentation will describe our eff­orts to develop related “shuttle catalysis” reactions for the functionalization and defunctionalization of organic compounds.1-5 These reactions avoid the use of toxic reagents (e.g. HCN, CO) through the reversible transfer of chemical moieties between organic molecules. Shuttle catalysis has further been employed in the development of novel C–X (X = S, P) bond metathesis reactions that can help to address significant synthetic challenges across the molecular sciences. Finally, some recent progress in the development of catalytic amination reactions will also be discussed.