Frances Arnold

Department of Chemical Engineering
California Institute of Technology
Friday, Oct. 26, 2018
3:00pm
Edward C Taylor Auditorium, Frick B02
Host
Todd Hyster
Add to Calendar2018-10-26 15:00:002018-10-26 15:00:00Todd HysterEdward C Taylor Auditorium, Frick B0215YYYY-MM-DD

2018 Nobel Prize in Chemistry to Frances Arnold!Congratulations Professor Arnold on winning the 2018 Nobel Prize in Chemistry!

 

Innovation by Evolution: Bringing New Chemistry to Life

Not satisfied with nature’s vast catalyst repertoire, we want to create new protein catalysts and expand the space of genetically encoded enzyme functions. I will describe how we can use the most powerful biological design process, evolution, to optimize existing enzymes and invent new ones, thereby circumventing our profound ignorance of how sequence encodes function. Using chemical intuition and mimicking nature’s evolutionary processes, we can generate whole new enzyme families that catalyze synthetically important reactions not known in biology. Recent successes include selective carbene insertion to form C-Si and C-B bonds, selective C-H insertion, and alkyne cyclopropanation to make highly strained carbocycles, all in living cells. Extending the capabilities and uncovering the mechanisms of these new enzymes derived from natural iron-heme proteins provides a basis for discovering new biocatalysts for increasingly challenging reactions. These new capabilities increase the scope of molecules and materials we can build using synthetic biology and move us closer to a sustainable world where chemical synthesis can be fully programmed in DNA.