Jwa-Min Nam

Department of Chemistry
Seoul National University
Friday, Jul. 6, 2018 2:00pm
Princeton Neuroscience Institute, Lecture Hall A32
Host
David MacMillan
Add to Calendar2018-07-06 14:00:002018-07-06 14:00:00David MacMillanPrinceton Neuroscience Institute, Lecture Hall A3215YYYY-MM-DD

Ultra-Tunable Nanoplasmonics for Biomedical Applications

Designing, synthesizing and controlling plasmonic metal nanostructures with high precision and high yield are of paramount importance in optics, nanoscience, chemistry, materials science, energy and biotechnology. In particular, synthesizing and utilizing plasmonic nanostructures with ultrastrong, controllable and quantifiable signals is key to the wide and practical use of plasmonic enhancement-based spectroscopies including surface-enhanced Raman scattering (SERS) and metal-enhanced fluorescence (MEF), but highly challenging. Here, I will introduce the design and synthetic strategies for molecularly tunable and structurally reproducible plasmonic nanogap structures with strong, controllable and quantifiable SERS, MEF and dark-field light scattering signals. I will also show their potentials in addressing some of important challenges in science, and discuss how these new plasmonic materials can lead us to new breakthroughs in biotechnologies including biosensing, bioimaging and theranostic applications.

 

 

 

 

 

 

 

 

References

Nanogap-Engineerable, Raman-Active Nanodumbbells for Single-Molecule Detection, Nature Materials, 9, 50 (2010).
Highly Uniform and Reproducible Surface-Enhanced Raman Scattering from DNA-Tailorable Nanoparticles with 1-nm Interior Gap, Nature Nanotechnology, 6, 452 (2011).
Plasmonic Nanosnowmen with a Conductive Junction as Highly Tunable Nanoantenna Structures and Sensitive, Quantitative and Multiplexable Surface-Enhanced Raman Scattering Probes, Nano Letters, 14, 6217 (2014).
Thiolated DNA-Based Chemistry and Control in the Structure and Optical Properties of Plasmonic Nanoparticles with Ultrasmall Interior Nanogap, J. Am. Chem. Soc., 136, 14052 (2014).
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Bio-Barcode Gel Assay for miRNA, Nature Communications, 5, 3367 (2014).
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Optokinetically Encoded Nanoprobe-Based Multiplexing Strategy for MicroRNA Profiling, J. Am. Chem. Soc., 139, 3558 (2017).
Associating and Dissociating Nanodimer Analysis for Quantifying Ultra-Small Amounts of DNA, Angew. Chem. Int. Ed., 56, 9877, (2017).

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