Mark Levin

Department of Chemistry
University of Chicago
Thursday, May. 27, 2021
Zoom Meeting
Rob Knowles
Add to Calendar2021-05-27 12:00:002021-05-27 12:00:00Rob KnowlesZoom Meeting15YYYY-MM-DD

Advancing Single Atom Logic for Skeletal Editing

Reactions which can manipulate the connectivity of the molecular skeleton are powerful tools for late-stage functionalization and enable unique synthetic routes, but their implementation has been hindered in part by their often nonintuitive retrosynthetic logic. This presentation will cover newly discovered transformations from our laboratory which enable single-atom changes to aliphatic and aromatic systems through the insertion and deletion of single heavy atoms (C,N,O, etc.). These new transformations are accomplished through a variety of strategic approaches spanning organic chemistry, organometallic chemistry, and photochemistry. Applications to late-stage functionalization and diversification of complex pharmaceutically relevant compounds as well as unique opportunities for synthesis will be presented alongside mechanistic findings.