Enantioselective Chemical Synthesis Methods via Cooperative Catalysis: Design, Development and Application
Our laboratory has embraced cooperative catalysis as a general framework for the design of new enantioselective reactions. Within this regime we have exploited cooperative Lewis base/transition metal catalysis as an effective means to control and direct both reaction partners during bond construction. The versatility of this approach is such that each catalyst acts in an orthogonal manner, which permits the role and function of the metal center to be modified and tuned without compromising enantioselectivity. This seminar will describe our most recent efforts in asymmetric carbon–carbon and carbon-nitrogen bond formation.