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David Nagib

Seminar
Wed, Mar. 13, 2019, 4:30pm
Edward C Taylor Auditorium, Frick B02
Host: David MacMillan

Speaker Details:

David Nagib

Department of Chemistry and Biochemistry
Ohio State University

Nagib Lab

Research Area:

Catalysis / Synthesis

C-H AND C-O FUNCTIONALIZATION VIA RADICAL CHAPERONES

Our research is focused on harnessing the untapped reactivity of abundant chemical feedstocks to enable late-stage functionalization of medicinally relevant molecules. We have recently developed new approaches for selective C-H and C-O functionalization of alcohols, amines, and carbonyls, using a combination of radical (1e-) and closed shell (2e-) processes that act in concert with one another. These radical chaperone strategies have enabled discovery of new classes of reactivity to streamline the synthesis of complex molecules with biological and industrial significance.