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Mary P. Watson

Mary P. Watson

Seminar
Tue, Sep. 30, 2014, 4:30pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Host: Robert Knowles
Speaker Details:
Mary P. Watson

Dept of Chemistry & Biochemistry
University of Delaware

Watson Lab
Research Area:
Catalysis / Synthesis

Transition Metal Catalysis of Non-traditional Electrophiles

We will present our research on the development of transition-metal catalyzed reactions employing non-traditional electrophiles. We have developed enantioselective, copper-catalyzed alkynylations of oxocarbenium ion intermediates, which enable efficient access to highly enantioenriched oxygen heterocycles with alpha stereogenic centers. We have also identified reaction conditions for enantiospecific, nickel-catalyzed cross couplings of amine- and alcohol-derived alkyl electrophiles. The optimization and scope of these transformations will be discussed, along with our mechanistic and stereochemical hypotheses and supporting experiments.