Mary P. Watson
Tue, Sep. 30, 2014, 4:30pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Host: Robert Knowles
Transition Metal Catalysis of Non-traditional Electrophiles
We will present our research on the development of transition-metal catalyzed reactions employing non-traditional electrophiles. We have developed enantioselective, copper-catalyzed alkynylations of oxocarbenium ion intermediates, which enable efficient access to highly enantioenriched oxygen heterocycles with alpha stereogenic centers. We have also identified reaction conditions for enantiospecific, nickel-catalyzed cross couplings of amine- and alcohol-derived alkyl electrophiles. The optimization and scope of these transformations will be discussed, along with our mechanistic and stereochemical hypotheses and supporting experiments.