MBLA Lecture: Koji Hirano & Kohsuke Ohmatsu
Mon, Oct. 17, 2022, 3:30pm
Princeton Neuroscience Institute, A32
Host: Martin Semmelhack and Erik Sorensen
Winners of the Merck-Banyu Lectureship Award
Dr. Koji Hirano, Development of New Bond Forming Strategies by Extended Umpolung
Dr. Hirano has extended the concept of traditional carbonylumpolung to aromatic compounds as well as hetero atom species and developed new C–C and C-heteroatombond forming strategies: 1)direct aromatic couplings via Cu- mediated C–Hactivation; 2)highly regio and enantioselective aminoboration and hydroamination of alkenes via Cu-mediated electrophilic amination; 3)C–C/C-P bond forming sequence and rapid construction of phospholes via Tf2O mediated electrophilic phosphination.These studies enable the otherwise challenging molecular transformations and greatly contribute to the development of organic synthetic chemistry.
Dr. Kohsuke Ohmatsu, Exploiting Ionic Molecules for Hitherto Difficult Catalytic Transformation
Dr. Ohmatsu has developed novel ionic ligands and ionic organocatalysts: 1) ion-paired ligand consisting of cationic achiral phosphine and chiral anion; 2) chiral onium−phosphine hybrid ligand; 3) chiral 1,2,3-triazolium ion having strong anion-binding ability. These catalysts enabled challenging asymmetric transformations such as construction of contiguous all-carbon quaternary stereocenters. He also developed a unique ionic radical catalyst: 4) zwitterionic triazolium amidate that allowed for efficient C(sp3)−H alkylation of various organic compounds.