Thu, Nov. 8, 2018, 4:30pm
Edward C Taylor Auditorium, Frick B02
Host: David MacMillan
Radical Reactions for Control Freaks: New Synthetic Methods Involving Aryl Radicals and Strong C–F Bonds
Over the past few years, our group has utilized photoredox catalysis to access highly-reactive radical intermediates. Our broader aims are centered on utilizing these intermediates to deliver structural motifs that are commonly found in drugs and agrochemicals. This lecture will include recent findings that have enabled us to overcome inherent difficulties in aryl radical reactivity, allowing for the development of highly chemoselective and switchable processes. Importantly, these studies have enabled the development of many other selective processes, including strategies for peptide functionalization and activation of very strong C–F bonds.