Tehshik Yoon
Stereocontrol in Photochemical Reactions
Wed, Sep. 25, 2024, 4:30pm
Taylor Auditorium, Frick Chemistry Lab B02
Host: SILS: Student Invited Lecture Series
Photochemistry is intriguing as a synthetic tool because the absorption of light by an organic molecule results in the formation of exceptionally energetic reactive intermediates that can react in ways that are inaccessible to ground-state molecules. However, this high reactivity is also a challenge for stereoselective synthesis: control over the stereochemistry of photochemical reactions, particularly using enantioselective catalysts, has been a long-standing challenging synthetic problem with few general solutions. We recently developed a strategy that utilizes privileged chiral Brønsted acid scaffolds to control both the absolute and relative stereochemistry of complex [2+2] photocycloadditions. These reactions have enabled a general, concise, and stereocontrolled strategy for the synthesis of the truxinate and truxillate natural products.