BMS Symposium: Dan Treitler & Jeff Bandar

Why Scaling Up is Hard: Lessons from Pharmaceutical Process Chemistry, Dan Treitler

Why do some reactions scale-up beautifully while others are disasters? What can a lab chemist do to help ensure success when scaling-up? This talk will address these questions using real examples from pharmaceutical processes run on scales from hundreds of grams to hundreds of kilograms.

New Concepts in Acid-Base Chemistry and Their Synthetic Applications, Jeff Bandar

Our group’s overarchinggoal is to establish new acid-base reactivity principles as a means to advance synthetic chemistry. For example, while base-promoted reactions typically accomplish redox neutral transformations, such as the addition of pronucleophiles to electrophiles, we have identified general strategies for base-promoted oxidativeand reductive coupling reactions. This talk will discuss the development of these strategies in the context of two methods: the oxidative coupling of C–H bondswith nucleophiles and the reductive defluorinative coupling of trifluoromethylarenes with electrophiles. The mechanistic frameworks of these methods will be compared to traditional base-promoted protocols to demonstrate unique capabilities and broad synthetic potential.To conclude, new perspectives of fundamental acid-base paradigms that are inspired by this work will be shown as the foundation for our group’s future directions.

Reception to follow in PNI Study Hall.