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BMS Symposium with Hao Xu

BMS Symposium with Hao Xu

Thu, Mar. 12, 2015, 2:00pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Host: Robert Knowles

2:00 p.m. – Introductory Remarks 

2:05 p.m.
Jennifer V. Obligacion, Bristol-Myers Squibb Fellow, Princeton University
“Base Metal Catalysis for the Synthesis of Organoboron Compounds”

2:30 p.m.
Jack Terrett, Bristol-Myers Squibb Fellow, Princeton University
“Merging Photoredox with Organocatalysis and Nickel Catalysis: Accessing Novel Mechanistic Platforms for C-C and C-O Bond Formation”

3:00 p.m. – Coffee Break

3:30 p.m.
Ashvin Gavai, Director, Oncology Chemistry, Bristol-Myers Squibb Research & Development 
“Discovery of PAN Notch Inhibitors as Novel Anti-Cancer Agents”

4:30 p.m.
Hao Xu, Department of Chemistry, Georgia State University

Searching for New Reactivity: Iron-Catalyzed Stereoselective Olefin Aminohydroxylation and Aminofluorination Reactions

Numerous pharmaceuticals contain at least one nitrogen atom and many of those nitrogen atoms are directly attached to stereogenic centers. Therefore, synthetic methods that incorporate selective nitrogen atom transfer to readily available hydrocarbons are important tools for the synthesis of these valuable molecules. While methods for selective olefin aziridination and direct C-H amination are well-established, methods for direct difunctionalization of olefins with a nitrogen atom and a range of heteroatom-based functional groups are less explored yet critically important to organic synthesis and its applications to the biomedical sciences.  The lecture is about the discovery and development of a series of iron-catalyzed nitrogen atom transfer reactions with an emphasis on stereoselective olefin aminohydroxylation and aminofluorination reactions.

5:30 p.m. – Wine Reception, Taylor Commons