Bradley S. Moore
Thu, Apr. 5, 2018, 4:30pm
Edward C. Taylor Auditorium, Frick B02
Host: Mohammad Seyedsayamdost
Learning and Applying Nature’s Biosynthetic Logic to Natural Product Molecules
Nature as a chemist continues to teach and inform us about the wonders of complex organic synthesis in a cell. Recent advances in genomics and metabolomics have ushered in a new era in natural products research linking genes to molecules. Synthetic biology programs now offer streamlined approaches to the discovery, production, and design of gene-encoded small molecules. This presentation will highlight recent progress in the genomics-guided discovery and chemoenzymatic synthesis of natural product small molecules, with a special focus on asymmetric oxidative cyclization reactions.