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Catharine Larsen

Catharine Larsen

Seminar
Tue, Mar. 3, 2015, 4:30pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Host: David MacMillan
Speaker Details:
Catharine Larsen

Department of Chemistry
University of California, Riverside

Larsen Research Group website
Research Area:
Catalysis / Synthesis
Inorganic Chemistry

Direct Catalytic Synthesis of Tetrasubstituted Carbons Bearing Amines and Heteroaromatics

​The direct formation of tetrasubstituted carbons bearing amines is rare—especially compared to the wide array of trisubstituted products accessible from multicomponent couplings of aldehydes, amines, and nucleophiles. Dual copper/titanium catalysis is required to overcome the barrier to condensation of a ketone with an amine and subsequent alkynylation, and copper-catalyzed Markovnikov alkyne hydroamination provides a unique alternate pathway to tetrasubstituted propargylamines. In addition, green solvent-free conditions provide one-step syntheses of alkyl- and pyridyl-substituted quinolines.