Wed, Feb. 11, 2015, 4:30pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Assembly Line Biosynthesis of Polyketide Antibiotics
Many polyketide antibiotics are synthesized by multi-enzyme systems that operate as assembly lines. Their apparently modular architecture suggests that it may be feasible to engineer new antibiotics by rationally manipulating the DNA encoding these megasynthases. Understanding the structures and mechanisms of these assembly lines represents a challenging and exciting frontier in 21st century enzymology. This lecture will provide an account of our understanding of the structures and mechanisms of assembly line polyketide synthases.