Jim Wells
Pirating proteins to attack the cancer surfaceome
Wed, Apr. 24, 2024, 4:30pm
Taylor Auditorium, Frick Chemistry Lab B02
Host: SILS
Speaker Details:
Harry Wm. and Diana V. Hind Distinguished Professor of Pharmaceutical Sciences
Department of Pharmaceutical Chemistry
University of California – San Francisco
The cell surface proteome, the surfaceome, is a major hub for cellular communication and a primary source of drug targets, especially for biologics. Identifying how the surfaceome changes in cancer is a central challenge for identifying and targeting new disease associated proteins. We have used chemical methods and engineered proteins to facilitate identification of membrane proteins, both native and post-translationally modified, that change with oncogene transformation. We then target proteins either upregulated, proteolyzed or both with recombinant antibodies or surface degraders as potential therapeutic leads.
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