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Keisuke Suzuki

Keisuke Suzuki

Tue, Oct. 1, 2019, 3:30pm
Edward C Taylor Auditorium, Frick B02
Host: Erik Sorensen

Lessons from Complex Natural Product Synthesis:

Cases of Carthamin and Spiroxins

The structural beauty and diversity of complex natural products derived from the polyketide type-II biosynthesis led us to study toward their total synthesis. This is a remarkable pathway that generates an impressive array of bioactive compounds with densely functionalized polycyclic architectures. The diversity is further enhanced by (1) post modifications, including oxidative de-aromatization, (2) dimerization, and (3) hybridization with other biosynthetic products, such as sugars and isoprenoids.1 This talk will deal with our recent syntheses of carthamine2 and the spiroxins.3