Pavel Nagorny

Development of new catalytic methods for the synthesis of natural products

This seminar will focus on our recent progress in developing new catalytic transformations for the synthesis of natural products. Our group has long-term interests in discovering and utilizing catalyst-controlled variants of the transformations that are traditionally believed to proceed through highly reactive oxocarbenium ion intermediates, and we will present our recent studies on chiral catalyst-controlled stereoselective spiroketalization, regioselective acetalization and catalyst-controlled regio- and stereoselective glycosylation reactions. In addition, the development and use of tandem Michael/Aldol/Aldol reactions for the rapid assembly of polyoxygenated cardiac steroids 19-hydroxysarmentogenin and trewianin aglycone will be presented.