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Steve Buchwald

Steve Buchwald

Seminar
Fri, Feb. 10, 2017, 4:30pm - 6:00pm
Frick Chemistry Laboratory, Taylor Auditorium
Host: David MacMillan
Speaker Details:
Steve Buchwald

Department of Chemistry
MIT

The Buchwald Research Group
Research Area:
Catalysis / Synthesis

ASYMMETRIC HYDROFUNCTIONALIZATION OF ALKENES

The availability of a general method for the catalytic conversion of olefins into enantiomerically enriched amines has eluded chemists for decades.  We have recently developed a simple copper-catalyzed method to effect such a transformation.  This lecture will describe our progress, applications of our methodology as well as our current view of the mechanism of the hydroamination process.  In addition, we will describe our progress in developing new methods for carbon-carbon bond formation that utilize alkyl copper intermediates.