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Takahiko Akiyama

Takahiko Akiyama

Seminar
Wed, May. 22, 2019, 4:30pm
Edward C Taylor Auditorium, Frick B02
Host: Dave MacMillan

Recent Progress in the Chiral Phosphoric Acid Catalysis

Development of efficient chiral catalysts continues to be one of the most important challenge in synthetic organic chemistry.  We already reported that chiral phosphoric acid 1, derived from (R)-BINOL functioned as bifunctional chiral Brønsted acid catalyst for a number of enantioselective reactions. We would like to discuss on the background why we developed chiral phosphoric acid, and the recent progress in the chiral phosphoric acid catalyzed enantioselective reactions such as transfer hydrogenation reactions, Friedel-Crafts reactions, internal redox reactions, and enantioselective synthesis of chiral biaryls.