Takashi Ooi

Molecular Design of Organic Ion Pairs for Asymmetric Catalysis

Molecules are probably the smallest units responsible for functions and are inherently
multidisciplinary as fields that deal with structurally well-defined molecular entities are
diverse. Synthetic chemistry is essential for the assembly of molecules by connecting or
breaking bonds in an efficient and predictable manner. Such endeavor always involves the
transformations of certain carbon feedstock to desired products. In developing ideal systems
for executing this fundamental process with the maximum efficiency and selectivity,
catalysts play a pivotal role. In this context, we have designed and synthesized a series of
structurally novel organic molecules, particularly chiral organic ion pairs, and succeeded in
eliciting their unique functions as molecular catalysts and ligands through rational structural
modifications, thereby leading to achieve highly selective bond-forming reactions based on
the precise control of ionic species. On the other hand, we have also elaborated new
molecules capable of catalytically controlling the radical-mediated bond constructions in
order to develop unconventional mode of chemical transformations by harnessing the
distinctive features of reactive radical species. In this lecture, I would like to present the
details of this research stream with particular focus on the recent advances.