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Tim Newhouse

Tim Newhouse

Thu, Oct. 11, 2018, 4:30pm
Edward C Taylor Auditorium, Frick B02
Host: Todd Hyster

The 2018 Millipore Sigma Lecture


Computationally Guided Total Synthesis of Neuroactive Terpenoids


Tim Newhouse, Assistant Professor of Chemistry, Yale

This talk will describe the total synthesis of neurologically active terpenoid natural products using novel strategies and methodologies for step-efficient syntheses. Methodological developments in the area of allyl-palladium catalysis will be described in detail that have allowed for alpha,beta-dehydrogenation of a variety of carbonyl compounds. Unique strategies and key retrosynthetic disconnections are guided by computational investigation.